Welcome to the Arnesen lab

 

We are a Research Group at the University of Bergen, Norway, located on the 6th floor of the Biomedical Building at the Department of Biomedicine. We take a variety of biochemical, molecular and cell  biology approaches to address fundamental questions related to the biology of protein modifications.

In particular we are interested in protein N-terminal acetylation. We study N-terminal acetyltransferases and how these enzymes influence cellular processes and human disease.

 

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n-terminal acetylation

Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation is one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.

The Arnesen lab is part of the Translational Cell Signaling and Metabolism (TSM) research group at the Department of Biomedicine, University of Bergen, Norway.

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RESEARCH NEWS

NAA10 mutation causes disabilities

Members of the Arnesen Lab have investigated a novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with intellectual disability and microcephaly.

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Cellular espionage

As the first lab in Norway, the Arnesen lab recently installed a HoloMonitor system from Phase Holographic Imaging for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.

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Researcher wanted

The Arnesen Lab is looking for a new Researcher. The position is external financed by the European Research Council (ERC) and for the time being a part of the project “Discovery and functional significance of post-translational N-terminal acetylation”. The project has a temporary financing for up to 3 years 6 months (project ends June 1st 2023)

Both standard and advanced methods in biochemistry and biophysics are needed to carry out this project

Application deadline October 6, 2019.

Publication of the year

The Arnesen Lab is proud to receive the University of Bergen Faculty of Medicine's publication of the year award for the back-to-back publications in PNAS

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility

and

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80

The work was performed by the following present lab members: Adrian Drazic, Henriette Aksnes, Sylvia Varland, Rasmus Ree, Line M. Myklebust, Markus Baumann, Nina Glomnes, and Thomas Arnesen along with alumni Marianne Goris, Håvard Foyn, Michaël Marie, Parminder Bhambra, and Svein I. Støve.


Last updated October 3rd, 2019.