Peer-reviewed research articles
Last updated October 29, 2023
2023
85. Sylvia Varland✉*, Rui Duarte Silva✉*, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho✉ & Thomas Arnesen✉ (2023). N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nature Commun 14(1):6774.
84. Laura Kind✉, Mark Driver, Arne Raasakka, Patrick R. Onck, Pål Rasmus Njølstad, Thomas Arnesen, Petri Kursula (2023). Structural properties of the HNF-1A transactivation domain. Front Mol Biosci Online ahead of print, doi: 10.3389/fmolb.2023.1249939.
83. Ulises H. Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E. Jakobsson, Lars J. Jensen, Thomas Arnesen✉ & Jesper V. Olsen✉ (2023). Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae. Nature Commun 14(1):4517.
82. Sylvia Varland✉, Kirsten Marie Brønstad, Stephanie J. Skinner, and Thomas Arnesen✉ (2023). A nonsense variant in the N-terminal acetyltransferase NAA30 may be associated with global developmental delay and tracheal cleft. Am J Med Genet A 191(9):2402-2410.
81. Line M. Myklebust, Markus Baumann, Svein I. Støve, Håvard Foyn, Thomas Arnesen✉, and Bengt Erik Haug✉ (2023). Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80. Front Chem 11:1202501.
80. D'Onofrio G, Cuccurullo C, Larsen SK, Severino M, D'Amico A, Brønstad K, AlOwain M, Morrison JL, Wheeler PG, Webb BD, Alfalah A, Iacomino M, Uva P, Coppola A, Merla G, Salpietro VD, Zara F, Striano P, Accogli A✉, Arnesen T✉, Bilo L (2023). Novel biallelic variants expand the phenotype of NAA20-related syndrome. Clin Genet in press doi: 10.1111/cge.14359.
79. Petra Van Damme✉, Camilla Osberg, Veronique Jonckheere, Nina Glomnes, Kris Gevaert, Thomas Arnesen, Henriette Aksnes✉ (2023). Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC. J Biol Chem 299(2):102824.
2022
78. Nina McTiernan, Lisbeth Tranebjærg, Anna S. Bjørheim, Jacob S. Hogue, William G. Wilson, Berkley Schmidt, Melissa M. Boerrigter, Maja L. Nybo, Marie F. Smeland, Zeynep Tümer, and Thomas Arnesen✉ (2022) Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N-terminal acetylation Hum Genet 141(8):1355-1369.
77. Laura Kind✉, Arne Raasakka, Janne Molnes, Ingvild Aukrust, Lise Bjørkhaug, Pål
Rasmus Njølstad, Petri Kursula, and Thomas Arnesen✉ (2022) Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants J Biol Chem 298(4):101803.
76. Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaël Marie, Sylvia Varland, Francis Impens, Kris Gevaert, and Thomas Arnesen✉ (2022) The final maturation state of β-actin involves N-terminal acetylation by NAA80 not N-terminal arginylation by ATE1 J Mol Biol 434(2):167397.
2021
75. Jennifer Morrison, Norah K. Altuwaijri, Kirsten Brønstad, Henriette Aksnes, Hessa S. Alsaif, Anthony Evans, Mais Hashem, Patricia G. Wheeler, Bryn D. Webb, Fowzan S. Alkuraya, and Thomas Arnesen✉ (2021) Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability and microcephaly Genet Med 23(11):2213-2218.
74. Rasmus Ree✉*, Karoline Krogstad*, Nina McTiernan, Magnus E. Jakobsson, and Thomas Arnesen✉ (2021) Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells Int J Mol Sci 22(21):11805
73. Hyae Yon Kweon, Mi-Ni Lee✉, Max Dorfel, Seungwoon Seo, Leah Gottlieb, Thomas PaPazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael Flory, Jonathan Crain, Alison Sebold, Scott Lyons, Ahmed Ismail, Elaine Marchi, Seong-keun Sonn, Se-Jin Jeong, Sejin Jeon, Shinyeong Ju, Simon J Conway, Taesoo Kim, Hyun-Seok Kim, Cheolju Lee, Tae-Young Roh, Thomas Arnesen, Ronen Marmorstein, Gootaeg Oh✉, and Gholson J Lyon✉ (2021) Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway eLife 10:e65952.
72. Ravi Kumar Dutta✉, Malin Larsson, Thomas Arnesen, Anette Heie, Martin Walz, Piero Alesina, Oliver Gimm, and Peter Söderkvist (2021) X-chromosome variants are associated with aldosterone producing adenomas Sci Rep 18;11(1):10562.
71. Tarsha L Ward, Warren Tai, Sarah U Morton, Francis Impens, Petra Van Damme, Delphi Van Haver, Evy Timmerman, Gabriela Venturini, Kehan Zhang, Min Young Jang, Jon AL Willcox, Alireza Haghighi, Bruce D Gelb, Wendy K Chung, Elizabeth Goldmuntz, George Arthur Porter, Richard Lifton, Martina Brueckner, H Joseph Yost, Benoit G Bruneau, Joshua Gorham, Yuri Kim, Alexandre C Pereira, Jason Homsy, Craig C Benson, Steven R DePalma, Sylvia Varland, Christopher S Chen, Thomas Arnesen, Kris Gevaert✉, Christine E Seidman✉, and Jonathan G Seidman✉ (2021) Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency Circ Res 128(8):1156-1169.
70. Kelly Velasco, Johanna L St-Louis, Henrikke N. Hovland, Nels Thompson, Åsta Ottesen, Man Hung Choi, Line Pedersen, Pål R. Njølstad, Thomas Arnesen, Karianne Fjeld, Ingvild Aukrust, Line M. Myklebust, and Anders Molven✉ (2021) Functional evaluation of sixteen SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro J Inherit Metab Dis 44(1):240-252.
69. Nina McTiernan, Harinder Gill, Carlos E. Prada, Harry Pachajoa, Juliana Lores, CAUSES study, and Thomas Arnesen✉ (2021) NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy Eur J Hum Genet 29(2):280-288.
2020
68. Bojan Krtenic✉, Adrian Drazic, Thomas Arnesen, and Nathalie Reuter✉ (2020) Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases PLoS Comput Biol 16(12):e1007988.
67. Rasmus Ree*✉, Laura Kind*, Anna Kaziales, Sylvia Varland, Minglu Dai, Klaus Richter, Adrian Drazic✉, and Thomas Arnesen (2020) PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin J Biol Chem 295(49) 16713–16731.
66. Nina McTiernan, Christine Darbakk, Rasmus Ree, and Thomas Arnesen✉ (2020)
NAA10 p.(D10G) and NAA10 p.(L11R) variants hamper formation of the NatA N-terminal acetyltransferase complex Int J Mol Sci 21(23):8973.
65. Ingrid Bader✉*, Nina McTiernan*, Christine Darbakk*, Eugen Boltshauser, Rasmus Ree, Sabine Ebner, Johannes A. Mayr, and Thomas Arnesen (2020) Severe syndromic ID and skewed X-inactivation in a girl with NAA10 dysfunction and a novel heterozygous de novo NAA10p.(His16Pro) variant - a case report BMC Medical Genetics 21:153.
64. Grzegorz Rebowski*, Malgorzata Boczkowska*, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, and Roberto Dominguez✉ (2020) Mechanism of Actin N-terminal Acetylation Science Adv 8;6(15).
63. Tobias B. Beigl, Monica Hellesvik, Jaakko Saraste, Thomas Arnesen, and Henriette Aksnes✉ (2020) N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus Exp Cell Res Mar 21:111961.
62. Angèle Abboud, Pierre Bédoucha, Jan Byška, Thomas Arnesen, and Nathalie Reuter✉ (2020) Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases Comput Struct Biotech 3;18:532-547.
61. Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen, and Ronen Marmorstein✉ (2020) Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK Nature Comm 11(1):818.
2019
60. Ravi Kumar Dutta, Thomas Arnesen, Anette Heie, Martin K Walz , Piero Alesina, Peter Söderkvist, and Oliver Gimm (2019) Case report: A somatic mutation in CLCN2 identified in a sporadic aldosterone producing adenoma Eur J Endocrinol 181(5):K37-K41
59. Rasmus Ree, Anni Sofie Geithus, Pernille Mathiesen Tørring, Kristina Pilekær Sørensen, Mads Damkjær, DDD study, Sally Ann Lynch, Thomas Arnesen (2019) A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly BMC Med Genet 20(1):101.
58. Stephen Ochaya, Oscar Franzén, Doreen Asiimwe Buhwa, Håvard Foyn, Claire E. Butler, Svein Isungset Støve, Kevin M. Tyler, Thomas Arnesen, Enock Matovu, Lena Åslund and Björn Andersson (2019) Characterization of evolutionarily conserved Trypanosoma cruzi NatC and NatA- N-terminal acetyltransferase complexes J Parasitol Res 2019:6594212.
2018
57. Varland S, Aksnes H, Kryuchkov F, Impens F, Van Haver D, Jonckheere V, Ziegler M, Gevaert K, Van Damme P, and Arnesen T (2018) N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae Mol Cell Proteomics 17(12):2309-2323
56. Aksnes H, Marie M, Arnesen T, and Drazic A (2018) Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin Commun Integr Biol 11(4):e1526572
55. Varland S, Arnesen T (2018) Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae BMC Res Notes 11:404.
54. Støve SI, Blenski M, Stray-Pedersen A, Wierenga KJ, Jhangiani SN, Akdemir ZC, Crawford D, McTiernan N, Myklebust LM, Purcarin G, McNall-Knapp R, Wadley A, Belmont JW, Kim JJ, Lupski JR, and Arnesen T (2018) A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability and hypertrophic cardiomyopathy Eur J Hum Genet 26(9):1294-1305
53. Cheng H, Dharmadhikari AV, Varland S, Ma N, Domingo D, Kleyner R, Rope AF, Yoon M, Stray-Pedersen A, Posey JE, Crews SR, Eldomery MK, Akdemir ZC, Lewis AM, Sutton VR, Rosenfeld JA, Conboy E, Agre K, Xia F, Walkiewicz M, Longoni M, High FA, van Slegtenhorst MA, Mancini GMS, Finnila CR, van Haeringen A, den Hollander N, Ruivenkamp C, Naidu S, Mahida S, Palmer EE, Murray L, Lim D, Jayakar P, Parker MJ, Giusto S, Stracuzzi E, Romano C, Beighley JS, Bernier RA, Küry S, Nizon M, Corbett MA, Shaw M, Gardner A, Barnett C, Armstrong R, Kassahn KS, Van Dijck A, Vandeweyer G, Kleefstra T, Schieving J, Jongmans MJ, de Vries BBA, Pfundt R, Kerr B, Rojas SK, Boycott KM, Person R, Willaert R, Eichler EE, Kooy F, Yang Y, Wu JC, Lupski JR, Arnesen T, Cooper GM, Chung WK, Gecz J, Stessman HAF, Meng L, and Lyon GJ (2018) Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies Am J Hum Genet 102(5):985-994.
Copyright PNAS
52. Goris M, Magin RS, Foyn H, Myklebust LM, Varland S, Ree R, Drazic A, Bhambra P, Støve SI, Baumann M, Haug BE, Marmorstein R, Arnesen T (2018) Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80 Proc Natl Acad Sci USA 115(17):4405-4410.
Commentary by Peter A. Rubenstein and Kuo-kuang Wen (2018) NATure of actin amino-terminal acetylation Proc Natl Acad Sci USA 115 (17) 4314-4316.
51. Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T (2018) NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility Proc Natl Acad Sci USA 115(17):4399-4404.
Commentary by Peter A. Rubenstein and Kuo-kuang Wen (2018) NATure of actin amino-terminal acetylation Proc Natl Acad Sci USA 115 (17) 4314-4316.
50. McTiernan N, Støve SI, Aukrust I, Mårli MT, Myklebust LM, Houge G, Arnesen T (2018) NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report BMC Med Genet 19(1):47.
49. Varland S, Myklebust LM, Strømsøy S, Glomnes N, Torsvik J, Varhaug JE, Arnesen T (2018) Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30 Gene 644:27-37.
2017
48. Grytaas MA, Strømsøy SS, Rørvik JT, Arnes JB, Heie A, Arnesen T, Jørstad MD, Nedrebø BG, Jøssang DE, Jensen DK, Rørvik HD, Sagen JV, Mellgren G, Thordarson HB, Husebye ES, Løvås K (2017) Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population Horm Metab Res 49(11):838-846.
47. Starheim KK, Kalvik T, Bjørkøy G, Arnesen T (2017) Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1-localization Biosci Rep 37(2). pii: BSR20170066.
46. Aksnes H, Goris M, Strømland Ø, Drazic A, Waheed Q, Reuter N, Arnesen T (2017) Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane J Biol Chem 292(16):6821-6837.
2016
45. Ribeiro AL, Silva RD, Foyn H, Tiago MN, Rathore OS, Arnesen T, Martinho RG (2016) Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion Sci Rep 6:39118.
44. Van Damme P, Kalvik TV, Starheim KK, Jonckheere V, Myklebust LM, Menschaert G, Varhaug JE, Gevaert K, Arnesen T (2016) A role for human N-terminal acetyltransferase Naa30 in maintaining mitochondrial integrity. Mol Cell Proteomics 15(11):3361-3372.
43. Osberg C, Aksnes H, Ninzima S, Marie M, Arnesen T (2016) Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. Sci Rep 6:31627.
42. Støve SI, Magin R, Foyn H, Haug BE, Marmorstein R, Arnesen T (2016) Crystal structure of the Golgi-associated human N-alpha acetyltransferase 60 reveals the molecular determinants for substrate-specific acetylation. Structure 24(7):1044-56.
41. Saunier C, Støve SI, Popp B, Gérard B, Blenski M, AhMew N, de Bie C, Goldenberg P, Isidor B, Keren B, Leheup B, Lampert L, Mignot C, Tezcan K, Mancini GM, Nava C, Wasserstein M, Bruel AL, Thevenon J, Masurel A, Duffourd Y, Kuentz P, Huet F, Rivière JB, van Slegtenhorst M, Faivre L, Piton A, Reis A, Arnesen T, Thauvin-Robinet C, Zweier C (2016) Expanding the Phenotype Associated with NAA10 Related N-terminal Acetylation Deficiency. Hum Mutat 37(8):755-64.
2015
40. Casey JP, Støve SI, McGorrian C, Galvin J, Blenski M, Dunne A, Ennis S, Brett F, King MD, Arnesen T, Lynch SA (2015) NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment. Sci Rep 5:16022.
39. Ree RM, Myklebust LM, Thiel P, Foyn H, Fladmark KE, Arnesen T (2015) The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Biosci Rep 35(5). pii: e00249.
38. Linster E, Stephan I, Bienvenut WV, Maple-Grødem J, Myklebust LM, Huber M, Reichelt M, Sticht C, Geir Møller S, Meinnel T, Arnesen T, Giglione C, Hell R, Wirtz M (2015) Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nature Commun 6:7640.
Copyright Proteomics
37. Van Damme P, Hole K, Gevaert K, Arnesen T (2015) N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. Proteomics 15(14):2436-46.
36. Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T (2015) An Organellar N-alpha Acetyltransferase, Naa60, Acetylates Cytosolic N-termini of Transmembrane Proteins and Maintains Golgi Integrity. Cell Rep 10(8):1362-74.
35. Myklebust LM, Van Damme P, Støve SI, Dörfel MJ, Abboud A, Kalvik TV, Grauffel C, Jonckheere V, Wu Y, Swensen J, Kaasa H, Liszczak G, Marmorstein R, Reuter N, Lyon GJ, Gevaert K, Arnesen T (2015) Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet 24(7):1956-76.
34. Popp B, Støve SI, Endele S, Myklebust LM, Hoyer J, Sticht H, Azzarello-Burri S, Rauch A, Arnesen T, Reis A (2015) De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females. Eur J Hum Genet 23(5):602-9.
2014
33. Van Damme P, Støve SI, Glomnes N, Gevaert K, Arnesen T (2014) A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase Naa10S37P mutant. Mol Cell Proteomics 13(8):2031-41.
32. Dutta RK, Welander J, Brauckhoff M, Arnesen T, Alesina P, Walz M, Söderkvist P, Gimm O (2014) Complementary somatic mutations in sporadic aldosterone producing adrenal adenomas Endocr Relat Cancer ERC 21(1):L1-4.
2013
31. Liszczak G, Goldberg JM, Foyn H, Petersson EJ, Arnesen T, Marmorstein R (2013) Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nature Struct Mol Biol 20(9):1098-105.
30. Arnesen T, Glomnes N, Strømsøy S, Knappskog S, Heie A, Akslen LA, Grytaas M, Varhaug JE, Gimm O, Brauckhoff M (2013) Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population based study from Western Norway. Langenbecks Arch Surg 398(6):869-74.
29. Aksnes H, Osberg C, Arnesen T (2013) N-Terminal Acetylation by NatC Is Not a General Determinant for Substrate Subcellular Localization in Saccharomyces cerevisiae. PLOS ONE 8(4): e61012.
28. Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T (2013) Design, Synthesis, and Kinetic Characterization of Protein N-Terminal Acetyltransferase Inhibitors. ACS Chem Biol 8:1121–1127.
Figure by Arnt Raae
27. Foyn H, Van Damme P, Støve S, Glomnes N, Evjenth R, Gevaert K, Arnesen T (2013) Protein N-Terminal acetyltransferases act as N-Terminal propionyltransferases in vitro and in vivo. Mol Cell Proteomics 12:42-54. Covered by ASBMB news.
2012
26. Grauffel C, Abboud A, Liszczak G, Marmorstein R, Arnesen T, Reuter N (2012) Specificity and Versatility of Substrate Binding Sites in Four Catalytic Domains of Human N-Terminal Acetyltransferases. PLoS ONE 7(12): e52642
25. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci USA 109(31):12449-54.
24. Evjenth R, Brenner A, Thompson PR, Arnesen T, Frøystein NÅ, Lillehaug JR (2012) The human protein N-terminal acetyltransferase hNaa50p (hNat5/hSan) follows an ordered sequential catalytic mechanism: A combined kinetic and NMR study. J Biol Chem 287(13):10081-8.
2011
23. Liszczak G, Arnesen T, Marmorstein R (2011) Structure of a ternary Naa50p (NAT5/San) Nα-terminal Acetyltransferase complex reveals the molecular basis for substrate specific acetylation. J Biol Chem 286(42):37002-10.
22. Hole K, Van Damme P, Dalva M, Aksnes H, Glomnes N, Varhaug J, Lillehaug JR, Gevaert K, Arnesen T (2011) The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS ONE 6(9): e24713.
21. Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T (2011) NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genet 7(7): e1002169.
20. Rope A, Wang K, Evjenth R, Xing J, Johnston JJ, Swensen JJ, Johnson WE, Moore B, Huff CD, Bird LM, Carey JC, Opitz JM, Stevens CA, Jiang T, Schank C, Fain HD, Robison R, Dalley B, Chin S, South ST, Pysher TJ, Jorde LB, Hakonarson H, Lillehaug JR, Biesecker LB, Yandell M, Arnesen T, Lyon GJ (2011) Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency. Am J Hum Genet 89(1):28-43. Comment in Nature News: doi:10.1038/news.2011.382
19. Helsens K, Van Damme P, Degroeve S, Martens L, Arnesen T, Vandekerckhove J, Gevaert K. (2011) Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation. J Proteome Res 10(8):3578-3589.
18. Van Damme P, Evjenth R, Foyn H, Demeyer K, De Bock P-J, Lillehaug JR, Vandekerckhove J, Arnesen T, Gevaert K. (2011) Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of Nα-acetyltransferases and point to hNaa10p as the posttranslational actin Nα-acetyltransferase. Mol Cell Proteomics 10: M110.004580.
2010
17. Gromyko D, Arnesen T, Ryningen A, Varhaug JE, Lillehaug JR (2010) Depletion of the human N-terminal acetyltransferase A (hNatA) induces p53-dependent apoptosis and p53-independent growth inhibition. Int J Cancer 127(12):2777-89.
16. Arnesen T, Starheim KK, Van Damme P, Evjenth R, Dinh H, Betts M, Ryningen A, Vandekerckhove J, Gevaert K, Anderson D. (2010) The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Mol Cell Biol 30(8):1898-909.
2009
15. Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR (2009) Human Naa50 (Nat5/San) displays both protein N-alpha and N-epsilon acetyltransferase activity. J Biol Chem. 284(45):31122-9.
14. Takubo K, Tsuchiya H, Kurimasa A, Arnesen T, Ryoke K, Shiota G. (2009) Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. Anti-Cancer Drugs.20:668-75.
13. Arnesen T, Gromyko D, Kagabo D, Betts MJ, Varhaug JE, Anderson D, Lillehaug JR. (2009) A novel human NatA Nα-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). BMC Biochem 10:15.
12. Starheim K, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T. (2009) Knockdown of the human NatC protein Nα-terminal acetyltransferase complex induces p53-mediated apoptosis and aberrant hArl8b localization. Mol Cell Biol 29(13):3569-81.
11. Arnesen T, Van Damme P, Polevoda B, Helsens K, Evjenth R, Colaert N, Varhaug JE, Vandekerckhove J, Lillehaug JR, Sherman F, Gevaert K. (2009) Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci USA. 106:8157-8162.
10. Målen H, Lillehaug JR, Arnesen T. (2009) The protein Nα-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells. BMC Res Notes 2:32.
2008
9. Starheim K, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR. (2008) Identification of the human Na-acetyltransferase complex B (hNatB) – a complex important for cell cycle progression. Biochemical J 415:325-331.
2006
8. Knappskog S, Geisler J, Arnesen T, Lillehaug JR, Lønning PE. (2006) A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family. Genes Chr. Cancer 45(12):1155-63.
7. Arnesen T, Betts M, Pendino F, Liberles D, Anderson D, Caro J, Kong X, Varhaug JE, Lillehaug JR. (2006) Characterization of hARD2, a processed hARD1 gene duplicate encoding a human protein N-α-acetyltransferase. BMC Biochem 7:13.
6. Arnesen T, Gromyko D, Pendino F, Ryningen A, Varhaug JE, Lillehaug JR. (2006) Induction of apoptosis in human cells by RNAi mediated knock-down of hARD1 and NATH, components of the protein N-α-acetyltransferase complex. Oncogene 25:4350-4360.
5. Arnesen T, Anderson D, Torsvik J, Varhaug JE, Lillehaug JR. (2006) Cloning and characterization of hNAT5/hSAN: An evolutionary conserved component of the NatA protein N-α-acetyltransferase complex. Gene 371:291-295.
2005
4. Arnesen T, Kong X, Evjenth R, Gromyko D, Varhaug JE, Lin Z, Sang N, Caro J, Lillehaug JR. (2005) Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α. FEBS Lett 579(28):6428-32.
3. Arnesen T, Gromyko D, Horvli O, Fluge Ø, Lillehaug JR, Varhaug JE (2005) Expression of NATH and hARD1 proteins in thyroid neoplasms Thyroid 15(10):1131-6.
2. Furnes C, Arnesen T, Askjaer P, Kjems J, Szilvay AM. (2005) HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain Retrovirology 2(1):39.
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