EPIC-XS Workshop 2021: Protein N-terminal processing and proteolysis

Thursday, February 25, 2021 15.30–18.00 CET via ZOOM

Please register for the workshop here: EPIC-XS Online Workshop Registration. The Zoom meeting link will be sent to all registered participants a few days in advance.

For information on upcoming EPIC-XS workshops in Computational, Clinical, Spatial, and Top-Down Proteomics and our workshop on Proteomics and Transcriptomics, check out the EPIC-XS event page.

16.00 -17.00 Protein N-terminal processing and proteolysis.

First series of talks from the University of Bergen (Thomas Arnesen’s lab), VIB-UGent Center for Medical Biotechnology, Gent (Kris Gevaert’s lab), and the University of Copenhagen (Olsen lab).

Chair: Thomas Arnesen University of Bergen (UiB)

16.00-16.15 Several modes of protein regulation by the acetyltransferase NAA10, Nina McTiernan (UiB)

16.15-16.30 Very little evidence for the contribution of non-coding transcripts to the complexity of the cytosolic proteome, Annelies Bogaert (VIB)

16.30-16.45 A potential role for NatA mediated N-terminal acetylation in protein turnover, Ulises Hernández Guzmán, University of Copenhagen (Olsen lab)

16.45-17.00 Q&A with the 3 speakers, moderated by Thomas Arnesen

17.00 -18.00 Protein N-terminal processing and proteolysis

Second series of talks from ETH Zurich (Paola Picotti’s lab), IMIC Czech Republic (Petr Man lab), and industrial speaker from Biognosys, Oliver Rinne.

Chair: Paola Picotti ETH Zurich

17.00-17.15 Barcoding the structural proteome with proteolytic probes, Valentina Cappelletti (ETH, Zurich)

17.15-17.30 Advantages of expanded protease portfolio in HDX-MS and protein characterization, Petr Man, (IMIC Czech Republic, Lab of structural Biology and Cell Signalling)

17.30-17.45 Applying limited proteolysis (LiP) for drug target deconvolution. An industry perspective. Oliver Rinner, Biognosys

17.45-18.00 Q&A with the 3 speakers, moderated by Paola Picotti