Arnesen Lab

We are a Research Group at the University of Bergen, Norway, located on the 6th floor in the Biomedical Building at the Department of Biomedicine. We take a variety of biochemical, molecular and cell biology approaches to address fundamental questions related to the biology of protein modifications.

In particular we are interested in protein N-terminal acetylation. We study N-terminal acetyltransferases and how these enzymes influence cellular processes and human disease.

background

n-terminal acetylation

Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation is one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.

The Arnesen lab is part of the Translational Cell Signaling and Metabolism (TSM) research group at the Department of Biomedicine, University of Bergen, Norway.

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RESEARCH NEWS

SHEDDING NEW LIGHT ON BRAIN CALCIFICATION

Brain calcification can cause movement disorders and cognitive impairment. Researchers at the Arnesen Lab at UiB have now identified a gene that provides new insight into how these calcifications occur. → Read more

UIB RESEARCHERS SOLVE PROTEIN MYSTERY

N-terminal acetylation shields proteins from degradation, which in turn affects motility and aging. → Read more

Removing Nt-acetylation increases the turnover of ribosomal proteins

The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. This research adds a piece to this puzzle. → Read more

First yeast NatC-focused N-terminomics

The yeast S. cerevisiae still serves as a valuable model for studying N-terminal acetylation. Together with our collaborators in Ghent, Arnesen lab now report the first yeast NatC-focused N-terminomics. → Read more

Pathogenic NAA20 variants discovered

Variants in different genes may cause developmental delay and various syndromes. Researchers from USA, Saudi Arabia and Norway recently uncovered pathogenic gene variants causing developmental delay and intellectual disabilities in a gene not previously linked to genetic disease. → Read more.

OTHER NEWS

NATS AT THE NBS CONTACT MEETING

Master student Åse Karine Bekkelund and PhD student Silje Kathrine Larsen presented their NAT-related posters at the Norwegian Bioscience Society (NBS) 59th Contact Meeting at Gol. → Read more

TMS STARTING GRANT

Henriette Aksnes from the Arnesen lab received the TMS Starting Grant for the project: "The role of membrane protein modifications in age-related brain pathology (MemBrain)". → Read more

KIND RECEIVES HER PHD DEGREE

Arnesen lab congratulates Laura Kind who successfully completed her trial lecture and PhD defense on the 12th of October. → Read more

Meltzer award and funding

Researcher Henriette Aksnes from the Arnesen lab was honored with the Meltzer award for young researchers → Read more
PhD candidates Hanne Øye and Laura Kind received Meltzer Project Grants.

MONICA HELLESVIK RECEIVES HSE AWARD 2022

Ph.d. candidate Monica Hellesvik from the Arnesen lab was honored with the Faculty of Medicine’s HSE award 2022.
→ Read more