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Photo: Margarethe Bittins. Copyright: UiB https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535072732244-VYYQ9165SU3OY6VC2SU3/model_nat6_-_pnas.jpg Putting a break on cell movement The enzyme NAA80 adds an acetyl group to actin and affects several cellular functions. Left: Usually, the enzyme NAA80 transfers an acetyl group to the N-terminus of actin. Right: When NAA80 is removed, actin is not acetylated. Actin filaments built from this type of actin are less dynamic, the cells have more filopodia and lamellipodia, and have increased motility. Photo: Drazic et al. Copyright: Adrian Drazic et al. https://www.arnesenlab.com/a-mutation-that-can-cause-autism daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535075359694-J7J2UBW9Q78NXHXN6B58/illustration_photo.jpg A mutation that can cause autism Photo: Leo Rivas Copyright: Unsplash https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535075420376-HGJZTZC3PJ9JOAURVY2N/figure_1.jpg A mutation that can cause autism Figure 1: Mutations identified in NAA15, a risk gene for autism spectrum disorders. Schematic representation of the genomic structure of human NAA15. Exons are shown as blue boxes and introns by connecting lines. The position of the genetic variants of NAA15 are shown and the number of affected individuals is indicated in parentheses. Photo: Cheng et al. Copyright: Cell Press https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535075556283-2IDNTWC9QBAEGNEPEKM0/sylvia_varland_002.jpg A mutation that can cause autism Sylvia Varland received a mobility grant from the Research Council of Norway to work at the University of Toronto. Photo: Joanna La Fleur Copyright: Sylvia Varland https://www.arnesenlab.com/hangin-out-at-the-golgi daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535076090441-HB39A3DWUR4DN6STOYNP/header_figure_w_en_tekst.jpg Hangin’ out at the Golgi https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535076206452-C21UEAVAJYCZLATO0DI7/figure_1_w_en_tekst.jpg Hangin’ out at the Golgi https://www.arnesenlab.com/naa60structuresolved daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535076610248-C1G6HD2UCMWJQG7HHUIK/naa60_cropped.jpg NAA60 structure solved Photo: Svein I. Støve. Copyright: Svein I. Støve. https://www.arnesenlab.com/new-naa10-mutations daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535077040485-MDGDYNZEYXUPPO1XYGI1/y43s_figure_cover.jpg New NAA10 mutations Naa10 homology model highlighting Tyr43 which was found mutated in two patients with intellectual disabilities. Copyright: Svein I. Støve https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535076985276-1MI3VQCEXTVN8A2K60HM/y43s_figure_1_4.jpg New NAA10 mutations Pedigree of the family with two brothers affected by the novel intellectual disability syndrome. Males are shown as squares, females as circles. The Naa10 c.128A>C (pY43S) point mutation occurred de novo in the mother of the two affected boys (individual II:2). Both her sons (individuals III:1 and III:2) inherited the Naa10 c.128A>C. Copyright: Svein I. Støve https://www.arnesenlab.com/new-hope-for-creating-droughtresistant-plants daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535077960886-9MTEPTPWGFUSD9OOIQAY/plante_figur_128_kb.jpg New hope for creating drought-resistant plants NatA depleted plants are resistant towards drought. NatA depleted plants (amiNaa10 and amiNaa15 plants) have a reduced growth (pattern) but were highly resistant to drought stresses and retained 95% of the water content of the leaves after a prolonged drought period (A). Wild type plants died after 20 days of drought and could not be rescued with resupply of water. NatA depleted plants did not show visible symptoms associated with water deficiency and after resupply with water, all NatA depleted plants continued to grow and produced viable seeds (B). https://www.arnesenlab.com/tension-release-by-nterminal-acetylation daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535078363677-ERUMDUD2MVGA25F4BDBX/aksnes_spotlight_figure_1_new150507.jpg Tension release by N-terminal acetylation Taking the N-end rule to the next level. A recent study links N-terminal acetylation and N-end rule degradation to blood pressure regulation. N-terminal mutants of Rgs2 (a key G-protein regulator) are found in patients with hypertension. These are differentially processed by N-terminal acetyltransferases (NATs) and the two branches of the N-end rule pathway. This leads to an imbalance in the signaling governing blood pressure. Refer to original potlight in TiBS for details. Copyright: Henriette Aksnes https://www.arnesenlab.com/cellular-gps-system-to-characterize-naa60 daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535078744191-2ILXFXM0SC9T83RYBQTI/bilde_1_2_0.jpg Cellular GPS system to characterize NAA60 A B C D E F Golgi. Henriette Aksnes and colleagues in the NAT group have found N-terminal acetylation to be common among transmembrane proteins and identified the first organellar N-terminal acetyltransferase NatF/Naa60, which localizes to the Golgi (pink). Copyright: Henriette Aksnes and Michaël Marie https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535079040124-ZUK5770EEBHGSXXX6P2K/fig_2_0.jpg Cellular GPS system to characterize NAA60 The microscope has been an important tool in this study. Researcher Henriette Aksnes finds it exciting to study protein properties by colouring them with fluorescent substances so that they are visible under the light microscope. In combination with other methods, the microscope is a valuable tool to reveal the important tasks that the NAT enzymes perform in the cell and the organism https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535078863728-PW4F1P5MYI4WVRMARO1D/fig_3_0.jpg Cellular GPS system to characterize NAA60 PROMPTing cells to reveal membrane protein topology. NatF/Naa60 was studied using a novel assay for the determination of membrane protein topology developed by Marc Niere and colleagues in Ziegler’s research group at UiB. This method utilizes directed localization of proteases in combination with a cleavable tag of green and red fluorescent protein. Copyright: Henriette Aksnes and Michaël Marie https://www.arnesenlab.com/aksnes-received-zona-award-2015 daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535079543307-049R0A2FH1UVKKCQEFKN/img_1622.jpg Aksnes receives ZONA award 2015 https://www.arnesenlab.com/uncovering-molecular-mechanisms-involved-in-the-ogden-syndrome daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535079964564-HPSPU0UHKBPV7A7C4WOS/img_1608.jpg Uncovering molecular mechanisms involved in the Ogden syndrome Line Merethe Myklebust and Svein Isungset Støve https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535079861128-2174696X3R3D6YHQOMCX/gutter_fra_familie_1_med_naa10_mutasjon__0.jpg Uncovering molecular mechanisms involved in the Ogden syndrome Boys affected by the Ogden syndrome have severe global developmental delays, reduced muscle strength, cardiac arrhythmias and craniofacial anomalies. All of the boys died before two years of age. So far eight boys from two unrelated families have been diagnosed with Ogden syndrome, caused by a point mutation in the gene NAA10 encoding the catalytic subunit of the NatA complex. https://www.arnesenlab.com/first-nat-inhibitors-and-structure daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535080133522-EMMOW92WK87NEWRWY9DD/Inhibitor.png First NAT inhibitors and structure Copyright: Thomas Arnesen https://www.arnesenlab.com/febs-congress-2018 daily 0.75 2018-08-29 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535578897037-M387J41XAPGBHS5FRYKC/IMG_4998.JPG FEBS Congress 2018 Adrian Drazic's poster "Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics" won the FEBS Letter daily poster award https://www.arnesenlab.com/hunger-is-not-a-hindrance-for-n-terminal-acetylation daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1543095663494-GH8RCHKCF4CHCT2NH09J/Christmas+cookies.jpg Hunger is not a hindrance for N-terminal acetylation Copyright: Unsplash https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1543453920299-J7BTUH9ZTQNYGLPQW4F3/Graphical+Abstract+-++Metabolism+.jpg Hunger is not a hindrance for N-terminal acetylation Graphic abstract: To address a potential impact of nutrient starvation on N-terminal acetylation yeast cells were grown in rich YPD medium and harvested at exponential active (6 hours), semi-active (day 3) and stationary (day 8) growth phase. N-terminal COFRADIC analysis on whole yeast extracts revealed that the global N-terminal acetylation levels remain largely unaffected by changes in cellular metabolism. However, two distinct sets of N-termini were differentially acetylated following starvation. The first protein cluster displayed generally increased N-terminal acetylation in stationary phase, despite a significant reduction in the cellular levels of acetyl-CoA. Similar to histone acetylation, the second protein cluster was generally less acetylated following entry to stationary phase. Copyright: Varland et al. https://www.arnesenlab.com/nbs-contact-meeting-2019 daily 0.75 2019-02-23 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547649321703-3TKDO01BJM1XC9LL346E/Ree%2BRasmus.jpg NBS Contact Meeting 2019 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547649368454-VHLKTUP8PUHWSSCBSHMD/Drazic%2BAdrian.jpg NBS Contact Meeting 2019 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547649447161-P5GXVTXRFLQ6TEDMMLZQ/Tobias_Beigl.jpg NBS Contact Meeting 2019 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547649412593-SDA5HEV3I64XFHD70B9G/Hellesvik%2BMonica_cropped.jpg NBS Contact Meeting 2019 https://www.arnesenlab.com/actin-modifications-finding-the-right-shoe-for-cinderella daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547473673934-J55U1GJXFU06KYTCPDAC/Cinderella_shoes.jpg Actin Modifications: Finding the Right Shoe for Cinderella Photo: colorbox.com. Copyright: colorbox.com https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547473250905-SER3BQGO6JAUV01MRDRZ/beta_actin.jpg Actin Modifications: Finding the Right Shoe for Cinderella This ribbon model of beta actin highlights the regions that often undergo post-translational modifications in red. 45% of all modifiable amino acids become modified. Beta actin has four subdomains, with an ATP moiety in the center, shown in yellow. Photo: Adrian Drazic https://www.arnesenlab.com/monica-hellesvik-wins-nbs-poster-award daily 0.75 2019-02-28 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1550956371264-QL5FFDUCTAYH1OI4L0O8/Monica+Hellesvik+NBS+Poster+award+2019.jpg Monica Hellesvik wins NBS poster award Surprised first place winner of the poster award, Monica Hellesvik, Master student in the Arnesen Lab. Photo: Arnesen lab https://www.arnesenlab.com/a-jack-of-all-trades-in-cancer-cells daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1552573975130-CALJ8ZZVFWG5Q62BNOI9/jack-of-all-trades-box2_0.jpg A Jack of all Trades in Cancer Cells Image with permission http://www.wopc.co.uk/ https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1552588102308-GRA4UX75V792TS7M2B8D/NAA10_functions_ver5_press-release.gif A Jack of all Trades in Cancer Cells Top: NAA10 in complex with NAA15 is an N-terminal acetyltransferase (NAT) acetylating 40% of our proteins when they are produced at the ribosome. Bottom: NAA10 is a lysine acetyltransferase (KAT) acetylating among others PGK1 and thereby initiates formation of autophagosomes. Image: Aksnes, Ree and Arnesen https://www.arnesenlab.com/diversity-our-strength- daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1587470312240-AXNY5L7S1E5A8I7FHSFY/Figure+1+andre-furtado-G5rzFysg9Ro-unsplash.jpg Sylvia Varland Donnelly Center Photo by Andre Furtado on Unsplash https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1587470603757-6XN197MXR0103URJZ2GL/Figure+2+Lab+life+at+the+Donnelly.png Sylvia Varland Donnelly Center Figure 2: Life at the Donnelly Center. Sylvia Varland celebrates May 17th, the Norwegian Constitution Day, in the cell culture lab (upper left). Adrian Drazic juggling cell lab work and the Ice Hockey World Championship (upper right). Two scientists, five weeks, a May 17 celebration and a Ice Hockey World Championship later Sylvia can show the samples ready for Illumina sequencing (lower left). Agar plates ready for SGA and an SGA triple mutant plate (lower right). Photo: Sylvia Varland https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1587470652614-XH8Z1UE5UXHZ3FVA3E1S/Figure+3+The+Canadian+experience.png Sylvia Varland Donnelly Center Figure 3: Canada can offer fantastic wildlife and scenic landscapes, as Lake Louise in Banff National Park. Photo: Sylvia Varland https://www.arnesenlab.com/naa10-mutation-causes-disabilities daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561945104377-10F4XLSYUUCSROMAFP0O/naa10_r83h.png NAA10 mutation causes disabilities The pathological varianten NAA10 R83H has a reduced enzymatic activity (a+c). Structural model of NAA10 where the altered amino acid (Arg83His) labelled in red is in direct contact with Acetyl Coenzyme A which donates the Acetyl group in the reaction (b). Arg83 is very conserved in NAA10 in different species supporting that the R83H alteration may be detrimental for protein function (d) Photo: Rasmus Ree et al. https://www.arnesenlab.com/drazic-receives-meltzer-award daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561945764106-HH2CSF7NN2A9ESZZY0S4/Meltzer_Drazic.jpg Adrian Drazic receives Meltzer Award for Outstanding Young Researchers Photo: Thor Brødreskift/UiB https://www.arnesenlab.com/jcs19meeting daily 0.75 2019-08-21 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1562024688591-SROWNSH9IJP6M7PPAP0U/Group-photo.jpg JCS19-Meeting Photo: https://www.biologists.com/meetings/celldynamics2019/ https://www.arnesenlab.com/donnelly-retreat-2019 daily 0.75 2019-07-29 https://www.arnesenlab.com/protein-termini-2019 daily 0.75 2019-08-14 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1565797559836-TKPH0MCBVTFSAORAUK20/Final+poster.jpg Protein Termini 2019 https://www.arnesenlab.com/nbs-contact-meeting-2020 daily 0.75 2020-01-30 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1562024762735-K0Y56GYX45N67YS35O63/NBS+logo.png NBS Contact Meeting 2020 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1579274794236-2TEHP94D6W2KBSN6GQO5/Varland%2BSylvia_1.jpg NBS Contact Meeting 2020 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1579274842451-WYIZEWD8AFEHM9YIMJWX/Hellesvik%2BMonica_cropped.jpg NBS Contact Meeting 2020 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1579276321860-61TFK9Q9KVGJH2K6K4PT/Aksnes%2BHenriette.jpg NBS Contact Meeting 2020 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1580397906826-SV02LDIBPMHPXN2UOMDY/Poster+wheel_cropped.jpg NBS Contact Meeting 2020 Photo: Henriette Aksnes https://www.arnesenlab.com/cellular-espionage-in-the-tissue-culture-lab daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561951182950-2BTXKIJINO5FNBNESWH6/tobias_with_laptop.jpg Cellular espionage in the tissue culture lab HoloMonitor-pioneer Tobias B. Beigl analyzing data in the accompanying software. Tobias is using the instrument for his master’s project as well as finalizing data for a paper together with supervisor Henriette Aksnes and bachelor students Emilie Seljeseth and Ine Kjosås. Photo: Monica Hellesvik https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561951911702-GAZE8P6R856ZW3QQ2RWR/holomonitor.jpg Cellular espionage in the tissue culture lab This neat microscope fits inside a regular cell incubator and monitors the cells during cultivation. It produces a 3D video of cell structure and behaviour. Photo: Phase Holographic Imaging AB https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561951922219-PJ58XFF9PQ2VKFFCRID9/migrating_cells.jpg Cellular espionage in the tissue culture lab Dividing cells. By means of its constant monitoring of cell volume, the HoloMonitor can automatically detect cell division events as these entail a sudden drop in cell volume of ~50%. Photo: Tobias Beigl https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1561951793655-T2JRCSQJ0YHPYVF6IEEV/cell_trajectories.jpg Cellular espionage in the tissue culture lab Migrating cells. An exemplary image showing how the HoloMonitor can be used to track the migration paths of cells. The path traveled by each cell is registered (represented by coloured line). The explanatory figure to the left shows how the trajectory of each cell can be overlayed in an x/y-position plot, called rose plot. The resulting “rose” is bigger for NAA80 knockout cells (right) as these cells migrate longer during the given timeframe compared to control cells (middle). This image is published in Communicative and Integrative Biology 2018 Photo: Henriette Aksnes https://www.arnesenlab.com/paper-of-the-year daily 0.75 2022-12-07 https://www.arnesenlab.com/motile-and-contractile-systems-2019 daily 0.75 2020-03-03 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1562024477700-Q2TV5MJKOQEXQOX8XJCW/ColbySawyer.jpg Motile and Contractile Systems 2019 Photo: https://www.grc.org/motile-and-contractile-systems-conference/2019/ https://www.arnesenlab.com/tagc-2020 daily 0.75 2020-04-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1580398272248-PXGOTW6EFGWACI9OEO6F/TAGC20-Twitter-Communities.jpg TAGC 2020 https://www.arnesenlab.com/tirfing-the-masters-degree-to-shore daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1580756416222-9S1VIIC4YCX4ZX4PRJ6G/2018-10-24_11.02.08_100x_ko2_6_h_laminin_coating_protocol_2019-12-02t12-35-54.533.jpg TIRFing the Master’s degree to shore Monica Hellesvik has been one of the pioneers to test the new TIRF microscope at the department. She needed to look closely at cell adhesive properties and the TIRF microscope was the perfect tool for it since it is particularly well suited for studying structures closest to the glass slides. This image shows a stained cell with adhesion patches in red and actin cytoskeleton in yellow/white. Photo: Monica Hellesvik https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1580756549442-3NM1TK73Y4TM0KWE10LA/20191206_1419102.jpg TIRFing the Master’s degree to shore From left: Henriette Aksnes, Monica Hellesvik Photo: Camilla Osberg https://www.arnesenlab.com/sdg-bergen daily 0.75 2020-02-07 https://www.arnesenlab.com/enzyme-upregulated-in-cancers-dissected-by-upenn-and-uib-researchers daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1581436102619-Z85IWYQI7RGW96BR9R59/nate_structure.png Enzyme upregulated in cancers dissected by UPenn and UiB researchers Image: Ronen Marmorstein https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1581436037936-ZD8N9R3JZ5IOAEWQ9RN4/nate-hypk_cryoem_natcomms.png Enzyme upregulated in cancers dissected by UPenn and UiB researchers Image: Ronen Marmorstein https://www.arnesenlab.com/protein-termini-2021 daily 0.75 2021-11-26 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1581683749638-6LYZWT8GJCUZXSJAX6DF/lachlan-gowen-AG3EcbcQOjw-unsplash.jpg Protein Termini 2021 Photo by Lachlan Gowen on Unsplash. https://www.arnesenlab.com/from-erasmus-internship-to-published-paper daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1585746526653-LUA2BUOCF3JAYZCS95S1/Beig+et+al+2020.png From ERASMUS internship to published paper Cells lacking NAA80 harbour unacetylated actin. The acetylation status of actin controls the structural integrity of the Golgi apparatus. Photo: Henriette Aksnes https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1585746681705-O5M0A5YMAI8V3MO3XGJR/figure_1.png From ERASMUS internship to published paper Figure 1. NAA80 knockout cells have an increased amount of actin fibers. This may be connected to the fragmented Golgi apparatus. Image from the article in Experimental Cell Research. Photo: Beigl. et al, 2020, Exp Cell Res. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1585746780858-VX0PJXEPHTJ27CQ340M3/figure_2.png From ERASMUS internship to published paper Figure 2. NAA80 knockout cells investigated with HoloMonitor M4. NAA80-lacking cells showed increased cell spread area, increased cell size and increased cell shape irregularity. Photo: Beigl et al., 2020, Exp Cell Res. https://www.arnesenlab.com/mechanism-of-a-cell-motility-regulator daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1586687425658-UNME3TYUR9DIREK1K1D1/figure_1_sciadv_2020.png Mechanism of a cell motility regulator Structure of actin (blue), profilin (light green) and NAA80 (purple) displaying the extensive interface between actin and NAA80 (yellow). Photo: Rebowski et al., Science Advances, 2020 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1586687480950-XPYHY59T07MZKK9L1IL2/sciadv2.png Mechanism of a cell motility regulator Photo: Rebowski et al., Science Advances, 2020 https://www.arnesenlab.com/aksnes-receives-falch-junior-award daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1589637504395-II3Q5LT7OECQUPV1LQYZ/foto_av_prisvinnere_fakdagen_2020.jpg Aksnes receives Falch Junior Award From the left: Marte Helene Bjørk, Henriette Aksnes og Nils Erik Gilhus.Photo: Silje Alvestad / Privat / Anne Sidsel Herdlevær https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1604494396580-FOGLHCIWO13Q1PZKT03I/image-asset.jpeg Aksnes receives Falch Junior Award Photo: Monica Hellesvik https://www.arnesenlab.com/research-from-home daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1600679259441-Z5Q8WVYUFL8O5J2H9G89/monica_hanne_henriette.jpg Research from home From left: Monica Hellesvik, Hanne Øye, and Henriette Aksnes. Photo: Screen shot https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1600679348479-5NPTNQ18WLCMF9ODTO49/holomonitor_m4.jpg Research from home In the Arnesen lab, the HoloMonitor is located in its own cell incubator, ready to spy on living cells. The microscope uses the gentle DHM technique, which is label-free. This enable us to monitor the cells for longer periods of time. Photo: Phase Holographic Imaging AB https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1600679425774-O7EJ4RY68OOR783P3RCD/roseplot.png Research from home The built-in software of the HoloMonitor allows us to quantify several different types of information about the cells. A "rose plot" visualizes the movement pattern of invading cancer cells from a time-lapse video similar to the above. Photo: Hanne Øye https://www.arnesenlab.com/the-cell-motility-regulator-naa80-is-assisted-by-profilin-2 daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1601280914080-JFGHCXNEGM4EKNUQUJCA/pfn2-naa80.png The cell motility regulator NAA80 is assisted by Profilin 2 https://www.arnesenlab.com/research-papers- daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535065410325-1CGBNWRIP5AMSPLMZAM4/pnas_115_17_cover_0.jpg Research papers Copyright PNAS https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535065743868-TU26A6A8ARMCGDQ4NBS1/2015-PROTEOMICS.jpg Research papers Copyright Proteomics https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535065356733-69DUWE856NB5AI0AW19A/n-terminal_acetylation_and_n-terminal_propionylation_by_arnt_raae_mbi_1.jpg Research papers Figure by Arnt Raae https://www.arnesenlab.com/naa10-variants daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1603210321396-CKHJTGBV4BJX55CH8YDL/image-asset.jpeg NAA10 variants https://www.arnesenlab.com/awesome-power-of-hap1-cells daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1605632288696-CQZUM2IA0VAPV972RXNN/Fig2+B_only.jpg Awesome power of HAP1 cells https://www.arnesenlab.com/epic-xs-workshops-2021 daily 0.75 2021-02-19 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1611950314442-7XQ8L1HV2DDOHI8DA7DL/EPIC-XS_logo_350x180_no_border.jpg EPIC-XS Workshops 2021 https://www.arnesenlab.com/naa15-linked-to-congenital-heart-disease daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1613165283954-NQRIZQ3RV41JCECRHTD4/melissa-labellarte-j_XVwZqzcdI-unsplash.jpg NAA15 linked to Congenital Heart Disease Photo by Melissa Labellarte on Unsplash. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1613164686574-W3SQINOETL17VEEHY15U/316966R3_316966_Graphical_Abstract.png NAA15 linked to Congenital Heart Disease Figure 1: Grapical abstract. This NAA15 study revealed 20 rare inherited or de novo variants that are thought to interfere with NAA15 function in people with congenital heart disease. Copyright: Circulation Research, an American Heart Association Journal. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1613164834106-AG6OWAZIPGG6RUIP61M1/Yeast+assay+with+NAA15+variants.png NAA15 linked to Congenital Heart Disease Figure 2: Yeast model for NAA15 gene variants. Yeast cells without the NatA complex (yNatA∆) grow slowly at 38°C, compared to normal cells (WT). Introduction of human NatA (NAA10 + NAA15) partially rescues the growth. Human NatA which expresses one of the mutated NAA15 variants D335fs or S761 * is not able to rescue the growth, indicating that the NatA function is impaired. Copyright: Circulation Research, an American Heart Association Journal. https://www.arnesenlab.com/pathogenic-naa20-variants daily 0.75 2023-01-03 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1625815905477-WXPD7NI1WEJXJ26EV141/gim-2021.jpg Pathogenic NAA20 variants - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/kind-receives-poster-award daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1628779966290-KLJPZXR5UBYYV0F0JRCR/unnamed.png Kind receives poster award - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/new-page-2 daily 0.75 2022-02-09 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/44fdc13c-5325-4827-8063-9e8e95b05620/thomas-arnesen.jpg Protein Termini 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/76b9959e-beb6-4da2-b9fe-01d314e1dc8e/henriette-aksnes.jpg Protein Termini 2022 - 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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/2019 daily 0.75 2022-12-06 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/fe04620d-2a95-415b-b51b-59ef57901072/2018-10-24_11.02.08_100x_ko2_6_h_laminin_coating_protocol_2019-12-02t12-35-54.533.jpg 2019 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/f5ee1b87-70ef-4bc7-8a7d-ad30fab0d367/naa10_r83h.png 2019 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/169d224d-d389-44cc-ae92-7d669023fa13/tobias_with_laptop.jpeg 2019 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c6bef66a-759e-498e-8d22-427cb94fd700/Meltzer_Drazic.jpeg 2019 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/e1b138d2-dd9d-4f9e-8b29-214caa202bf3/NAA10_functions_ver5_press-release.gif 2019 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/5e63ec3d-fd91-466b-b97d-e842feb75e35/Cinderella_shoes.jpeg 2019 - Make it stand out Copyright: colorbox.com https://www.arnesenlab.com/20152016 daily 0.75 2022-12-06 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4fbcf26d-52e7-4437-b0bc-6fc022096d38/naa60_cropped.jpeg 2015-2016 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/669d6a94-aabf-4562-afbe-8e12b1d107d2/y43s_figure_cover.jpeg 2015-2016 - Make it stand out Copyright: Svein I. Støve https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/da1cb246-e481-455a-a40f-c83abc70ca20/plante_figur_128_kb.jpeg 2015-2016 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4e3f872b-66b4-469e-bef0-7377dcec174e/aksnes_spotlight_figure_1_new150507.jpeg 2015-2016 - Make it stand out Copyright: Henriette Aksnes https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/84e7d1f1-30a6-410d-beaf-a6f07fae49bb/bilde_1_2_0.jpeg 2015-2016 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/9791b486-ad8b-4f3d-94c9-39df53aae399/img_1622.jpeg 2015-2016 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/d5546a90-ef63-4eb3-8b01-47b5bcce5e6f/img_1608.jpeg 2015-2016 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/7ab19d3d-ea31-4ea9-9e7e-b2ae09b43b9c/Inhibitor.png 2015-2016 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/20172018 daily 0.75 2022-12-06 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/f5ecac55-98ff-41c1-9cd8-825cd59e8756/Graphical%2BAbstract%2B-%2B%2BMetabolism%2B.jpeg 2017-2018 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/60de0499-b959-44da-a6ab-19ce8f4576e5/illustration_photo.jpeg 2017-2018 Photo: Leo Rivas Copyright: Unsplash https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4fd62d54-00c2-4e7e-8ca1-e601123302c3/img_5320_mod.jpeg 2017-2018 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/bf2e8706-5893-40ce-85d1-0d6922b47138/header_figure_w_en_tekst.jpeg 2017-2018 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/caiella-wins-poster-award-embo daily 0.75 2022-12-06 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4affa0ff-990a-40a4-96d1-806362412cb9/MicrosoftTeams-image+%288%29.jpeg Caiella wins poster award EMBO Photo: Laura Kind https://www.arnesenlab.com/research-group-of-the-year-2021 daily 0.75 2022-12-08 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4f15cca7-bb96-4b88-9ad2-e272897d0e01/Thomas+Arnesen+og+Marit+Bakke.jpg Research group of the year 2021 - Make it stand out Photo: Jørgen Barth https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/3086f0a5-737c-4cde-a4f0-53cfa39f8351/MicrosoftTeams-image+%288%29.png Research group of the year 2021 - Make it stand out Photo: Private https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/fa061d56-6597-4cef-b3b6-c9a702b150c7/MicrosoftTeams-image+%289%29.jpeg Research group of the year 2021 - Make it stand out Photo: Private https://www.arnesenlab.com/kind-best-poster-award-2022 daily 0.75 2022-12-07 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/fd1a49d0-5f6b-4dc9-b75d-112385586e75/Kind%2BPoster%2BAward_diabetes%2Bmeeting%2B2022.jpeg Kind Best Poster Award 2022 - Make it stand out Photo: Pål R. Njølstad https://www.arnesenlab.com/saraste-transitions-to-emeritus daily 0.75 2022-12-12 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/60d9ea7f-80e0-4e0c-998d-0035f75d15ed/Bilde1.png Saraste transitions to Emeritus - Make it stand out Photo by: Endy Spriet https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/729d8c85-f0d1-44ac-a90d-f79576009914/Bilde2.png Saraste transitions to Emeritus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/mctiernan-phd daily 0.75 2022-12-13 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c290c23f-f2dd-4dbd-9cbd-219412c617ab/Nina+Mc+Tiernan_SH.jpg McTiernan PhD - Make it stand out Photo by: Jørgen Barth https://www.arnesenlab.com/yeast-natc-nterminomics daily 0.75 2023-01-03 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/af59d890-d06a-4fa3-b0c6-c9625b2e2d58/ynatc-jbc.jpeg Yeast NatC N-terminomics - Make it stand out Photo: Henriette Aksnes https://www.arnesenlab.com/2022 daily 0.75 2023-01-03 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/8872ae13-610e-4bb3-a762-5bbc7af1a40b/ynatc-jbc.jpeg 2022 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/f2442ba2-fa21-4207-8e92-38f238bc491b/Skjermbilde+2023-01-03+kl.+17.39.28.png 2022 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/06ae1655-0eb6-458a-9103-5087454b7b97/Bilde1.png 2022 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/e22e378d-f650-4895-b37f-db8c3de1893d/MicrosoftTeams-image%2B%288%29.jpeg 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/bfd5f1e9-54f6-4050-b642-360f8c699bcc/MicrosoftTeams-image%2B%289%29.jpeg 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/3a3b84fd-2884-42c7-8d4b-5ac67eb4dc5a/Kind%2BPoster%2BAward_diabetes%2Bmeeting%2B2022.jpeg 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/hellesvik-receives-hse-award daily 0.75 2023-02-22 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/bbc923f3-eb66-49fe-a432-e43e696c14c7/MicrosoftTeams-image.png Hellesvik receives HSE award - Make it stand out Monica Hellesvik receives HSE award 2022 from the Faculty of Medicine. The award was announced by Senior Executive Officer Lise Skålvik Amble and Deputy Director General Heidi Annette Espedal at the annual HSE day. Photo: Jørgen Barth, UiB. https://www.arnesenlab.com/meltzer-award-2023 daily 0.75 2023-03-13 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/728cb35d-b2fe-41df-8028-6f706aa46536/meltzerprisen_foto_thor_brodreskift_1-2.jpg Meltzer Award 2023 - Make it stand out Photo: Thor Brødreskift https://www.arnesenlab.com/removing-ntac-increases-ribosomal-protein-turnover daily 0.75 2023-08-14 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/ad900d91-ad84-4a79-8789-af5fffb594e6/ynata_bilde_v2_2023.jpg Removing NtAc increases ribosomal protein turnover - Make it stand out In normal (WT) yeast, approximately 30% of the proteome is N-terminally acetylated by the NatA enzyme. In naa10-delta yeast, the catalytic subunit of the NatA complex (Naa10) is deleted, resulting in a dysfunctional NatA complex. In these cells, the proteins starting with small amino acids (A, alanine; S, serine; T, threonine; V, valine, and G, glycine) are not N-terminally acetylated. This results in a reduced thermostability of ribosomes and a high turnover rate of many ribosomal proteins. Photo: Aksnes et al. https://www.arnesenlab.com/kind-phd daily 0.75 2023-10-18 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/b3f64080-5276-45e0-98e3-0432672a1d24/Laura%2BKind_v2_.jpg Kind PhD - Make it stand out Foto/ill.: unknown (photography studio) https://www.arnesenlab.com/uib-researchers-solve-protein-mystery daily 0.75 2023-12-05 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c8e400ea-2756-43b3-a632-c59177f7016a/bilde2_26.jpg UiB researchers solve protein mystery - Make it stand out Figure 1: N-terminal acetylation by NatC shields proteins from degradation. (Left) The NatC complex acetylates proteins harboring a hydrophobic residue in the second position (MΦ). Following Nt-acetylation, Ac-UBE2M and Ac-UBE2F promote cullin neddylation (N8), resulting in ubiquitylation (Ub) and proteasomal degradation of targeted cullin substrates, Ac-ARFRP1 is targeted to the Golgi where it plays a role in the secretory pathway, while the hypothetical proteins Ac-X and Ac-Y are thought to affect the secretory pathway and mitochondria, respectively. (Right) Loss of NatC exposes unacetylated MΦ-starting N-termini which serves as N-degrons that can be recognized by a set of N-recognins leading to proteasomal and, in some cases, lysosomal degradation. Non-Nt-acetylated NatC substrates are primarily targeted by the ubiquitin ligases UBR4-KCMF1 and to some extent UBR1 and UBR2. Targeted degradation of non-Nt-acetylated NatC substrates leads to decreased cullin neddylation, increased mitochondrial elongation and fragmentation, and is thought to affect intracellular trafficking. (Figure from Varland, Sylvia et al, 2023, Nature Communications). Photo: Varland, m.fl. https://www.arnesenlab.com/tms-starting-grant daily 0.75 2023-12-05 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/23ce68ee-3c21-4392-a50c-84ba49453fa9/tms_4.jpg TMS Starting Grant - Make it stand out From left: Henriette Aksnes at the The Department of Biomedicine (Arnesen lab), Gabriele de Seta at the Department of Linguistic, Literary and Aesthetic Studies and Jana Birke Belschner at the Department of Comparative Politics, are this year's recipients of the TMS Starting Grant. Photo: Melanie Burford/ Trond Mohn stiftelse https://www.arnesenlab.com/nbs2024 daily 0.75 2024-03-15 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/e7dddc5b-bf92-417a-a7e5-0d4d9fb33598/NBS.png NBS-2024 - Make it stand out Photo: Private https://www.arnesenlab.com/shedding-new-light-on-brain-calcification daily 0.75 2024-03-15 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4d7010de-dcb5-4906-8c3f-330d721b017c/hjernekalk.jpg Shedding new light on brain calcification - Make it stand out CT scan of a patient with brain calcification. Photo: Viorica Chelban. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/341b731c-0395-400c-a6d1-95086deabe89/aksnes.jpg Shedding new light on brain calcification - Make it stand out Henriette Aksnes’ talk at the EMBO conference June 2022. Photo: Laura Kind https://www.arnesenlab.com/2024 daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/0311f966-5b7d-48c9-9b71-d6f8847cccd1/Picture+2.png 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4d7010de-dcb5-4906-8c3f-330d721b017c/hjernekalk.jpg 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/3777f01f-c679-4a2c-9be3-38f5d29a3f86/NBS2.png 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/2023 daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/23ce68ee-3c21-4392-a50c-84ba49453fa9/tms_4.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/b3f64080-5276-45e0-98e3-0432672a1d24/Laura%2BKind_v2_.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c8e400ea-2756-43b3-a632-c59177f7016a/bilde2_26.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/8876b464-2a53-4e3e-8be4-54be70b800e9/meltzerprisen_foto_thor_brodreskift_1-2+copy.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/ad900d91-ad84-4a79-8789-af5fffb594e6/ynata_bilde_v2_2023.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c80e4335-0217-4fe9-ba48-4a59e08f4ea1/MicrosoftTeams-image.jpg 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/oxygen-sensors-in-human-cells daily 0.75 2025-01-30 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/a91c1ca5-99df-4b99-bad4-eda4caefd48f/Picture+2.png Oxygen sensors in human cells - Make it stand out Photo: Karen Heathcote et al. https://www.arnesenlab.com/oye-phd daily 0.75 2025-04-28 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/51dc18ed-a06d-487b-867b-c4db60a700b8/HanneOye.png Øye PhD - Make it stand out Photo: Hanne Øye https://www.arnesenlab.com/2025 daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/dcff3f5f-807b-4ef1-a969-70f56ee6ee64/IBM_Arnesen+gruppen_Image+2606-2025.jpg 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/51dc18ed-a06d-487b-867b-c4db60a700b8/HanneOye.png 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/c7303770-27fb-4cfb-9249-48693d0aa05c/cover_tibs.jpg 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.arnesenlab.com/decoding-human-biology-one-protein-at-a-time daily 0.75 2025-08-12 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/dcff3f5f-807b-4ef1-a969-70f56ee6ee64/IBM_Arnesen+gruppen_Image+2606-2025.jpg Decoding human biology one protein at a time - Make it stand out From left: Matti Myllykoski, Camilla Osberg, Malin Lundekvam, Thomas Arnesen. Photo: Ine Kjosås, UiB https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/8aa7e95c-359b-4634-ad3b-9bad5e3cbbc7/NAT16.png Decoding human biology one protein at a time - Make it stand out Photo: Matti Myllykoski et al. https://www.arnesenlab.com/people daily 0.75 2025-11-04 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1547331327290-15IHN7CXBMHXMVF4UK1N/Arnesen%2BThomas.jpg People PhD, Molecular Biology, University of Bergen, 2006 ORCID | ResearchGate | Twitter https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/7e681c38-4dff-4c07-843b-03dabead22fb/saraste.jpg People - Make it stand out PhD, Molecular Biology, University of Helsinki, 1981 ORCID | ResearchGate https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/11d07091-b315-4083-b4c6-fa74dc6b1673/matti_.jpg People PhD, Biochemistry University of Oulu, 2013 ORCID https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/4a6bf5d3-144a-4de6-afba-be24e8b99d2a/1.jpg People PhD, Biomedical Sciences, University of Bergen, 2025 ORCID | ResearchGate https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1535399425258-HYLIAHWASC02P3L52A18/Nina+McTiernan.JPG People PhD, Biomedical Sciences, University of Bergen, 2022 ORCID | ResearchGate https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1629213346331-TFXXEAFW4JWC05MYOF36/Kjos%25C3%25A5s%2BIne_cropped.jpg People MSc, Molecular Biology, University of Bergen, 2021 ORCID | ResearchGate https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1626091746379-K82P6CMIT13OWILI4Y7S/Alessia+Caiella.jpg People - Make it stand out MSc, Biomedical Sciences, University of Bergen, 2021 Main supervisor: Henriette Aksnes https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1635319288074-4MAX11NXM6ZDSKQQT3JU/Lundekvam%2BMalin.jpg People MSc, Molecular Biology, University of Bergen, 2022 ORCID https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1629902004689-FBX13JK7L49I582YGGYL/Hellesvik+Monica_v2.png People MSc, Molecular Biology, University of Bergen, 2019 ORCID | ResearchGate https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1a847b42-92ae-41bb-802d-5d16eaca7496/Anette.jpg People MSc, Biomedical Sciences, University of Bergen, 2023 Main supervisor: Henriette Aksnes https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1630736217044-7AYEBA3FCE2CIB754E0S/Antu_im-invisible-user.svg.png People Master student https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1601575868617-PB3EH7V0G0TSZXJRZHBN/Invisible+user.jpg People Master student https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1615630285970-X0L0FCIRB2O7HINKA5FA/Antu_im-invisible-user.svg.png People - Make it stand out Master student https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1534909413580-UOTO4EKOQJB1M42W6RS7/Osberg+Camilla.jpg People Senior Engineer PhD, Molecular Biology, University of Bergen, 2016 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1604666603862-2C3OKEYAE2G5TTHUZK3D/Glomnes%2BNina.jpg People - Make it stand out Research Technician https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/1603375540321-EAQTLLL0X2DYPRSFBI71/Kirsten.jpg People Staff Engineer, TSM group https://www.arnesenlab.com/new-molecular-insights-into-early-protein-maturation daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/fd73c10a-cc4c-4056-8ab7-5aac027cb1ab/News2.png New molecular insights into early protein maturation - Make it stand out Photo: Marius Klein et al. https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/dd3fb8f6-f38f-471c-8774-cc3611bd6148/News1+copy.png New molecular insights into early protein maturation - Make it stand out Photo: Marius Klein et al. https://www.arnesenlab.com/2026 daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5b7c73223917eefb347e4264/fd73c10a-cc4c-4056-8ab7-5aac027cb1ab/News2.png 2026 - Make it stand out Whatever it is, the way you tell your story online can make all the difference.